LGP2, NT (D11LGP2, D11LGP2E, DEXH (Asp-Glu-X-His) Box Polypeptide 58, DHX58, Probable ATP-dependent RNA Helicase DHX58, Probable ATP-dependent Helicase LGP2, Protein D11Lgp2 Homolog, RIG-I-like Receptor LGP2, RLR)

Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Immunohistochemistry...