IRAK 2 (Interleukin-1 Receptor-associated Kinase 2, IL-1 Receptor-associated Kinase 2, Interleukin-1 Receptor-associated Kinase-like 2, IL-1 Receptor-associated Kinase-like 2, IRAK2, IRAK-2, MGC150550)

The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants...