Alterations and deletions within the FHIT (Fragile Histidine Triad) gene and concomitant perturbations of FHIT gene expression are strongly linked to the genesis and establishment of human tumors of the lung (1–3), cervix (4,5), breast (6,7), stomach (8), pancreas (9), and other tissues. Originally identified by collaborating researchers in the U.S. and Japan (10), the > 500 kbp FHIT gene was shown to span the fragile chromosomal site FRA3b (11) at band 3p14.2. These researchers and subsequent others demonstrated that loss of heterozygousity or homozygous deletion at this locus are characteristics...
Alterations and deletions within the FHIT (Fragile Histidine Triad) gene and concomitant perturbations of FHIT gene expression are strongly linked to the genesis and establishment of human tumors of the lung (1–3), cervix (4,5), breast (6,7), stomach (8), pancreas (9), and other tissues. Originally identified by collaborating researchers in the U.S. and Japan (10), the > 500 kbp FHIT gene was shown to span the fragile chromosomal site FRA3b (11) at band 3p14.2. These researchers and subsequent others demonstrated that loss of heterozygousity or homozygous deletion at this locus are characteristics...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CROSS REACTIVITY
Hu Rt
CLASS
Polyclonal Antibodies
SUBCLASS
Transcription Factors
APPLICATION
E IHC WB
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by immunoaffinity chromatography.
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with R-Phycoerythrin (PE).
GRADE
Affinity Purified
ANTIBODY TYPE
Pab
HOST SPECIES
human
ISOTYPE
IgG
IMMUNOGEN
Full length human FHIT fusion protein with GST (glutathione amino transferase)
SPECIFIC ACTIVITY
Recognizes human FHIT at ~17kD. Reactivity has been confirmed by Western Blot using lysates from rat brain, colon, spleen, stomach, kidney, lung, small intestine and testes as well as 293T cells and COS cells transfected with a pCMV-FHIT-FLAG construct. Species Crossreactivity: Rat. Does not react with mouse.
COMMODITY CODE
30021010
HOST
rabbit
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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