EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2,-3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head and neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Applications:
Suitable for use in Immunoprecipitation and Immunohistochemistry. Not suitable for use in Western Blot. Other applications not tested.
Recommended...
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2,-3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head and neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Applications:
Suitable for use in Immunoprecipitation and Immunohistochemistry. Not suitable for use in Western Blot. Other applications not tested.
Recommended...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Monoclonal Antibodies
SUBCLASS
Receptors, Growth Factor
APPLICATION
IHC IP
CLONE NUMBER
3H2090 (ICR10)
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by Ion Exchange chromatography.
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase.
GRADE
Highly Purified
ANTIBODY TYPE
Mab
HOST SPECIES
human
ISOTYPE
IgG2a
CROSS REACTIVITY
Hu
IMMUNOGEN
Extracellular domain of human EGF-receptor from head and neck carcinoma.
SPECIFIC ACTIVITY
Recognizes the human epidermal growth factor receptor (EGF-R), which is overexpressed in a high proportion of breast cancer cells and in a range of other carcinomas. High level expression of EGFR is often associated with advanced disease and poor prognosis. Binds to epitope B from EGFR and has an affinity of 6.7x10e-9M.
SWISS PROT#
P00533
COMMODITY CODE
30021010
HOST
rat
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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