EphA1, Fc Chimera, Recombinant, Human (Ephrin-A1, EPH-related Receptor Tyrosine Kinase Ligand 1, LERK-1, Immediate Early Response Protein B61, Tumor Necrosis Factor alpha-induced Protein 4, TNF alpha-induced Protein 4, EFNA1, EPLG1, LERK1, TNFAIP4)

Ephrin-A1, also known as B61 and LERK-1, is a member of the Ephrin-A family of GPI-anchored ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. Ephrin-A ligands are structurally related to the extracellular domains of the transmembrane Ephrin-B ligands. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Human Ephrin-A1 is synthesized with an 18aa signal peptide, a 164aa mature chain, and a 23aa C-terminal propeptide which is removed prior to GPI linkage of Ephrin-A1 to the membrane. It can also...