CD146 (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM) (PE)

MUC18, also known as CD146, Mel-CAM, A32 antigen, S-Endo-1, and MCAM, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. This protein has been localized to the cell-cell junction in all endothelial cells and has also been observed in other normal and malignant cell types. In addition to its recognized role as a calciumindependent cell adhesion molecule, MUC18 may also act as a signal transduction molecule in the recruitment of the Fyn kinase and the subsequent tyrosine-phosphorylation of intracellular proteins involved in the dynamics of the actin cytoskeleton. MUC18...