The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKBa or RacPK), Akt2 (also designated PKB-b or RacPK-b) and Akt3 (also designated PKB-g or thyoma viral proto-oncogene 3). Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-b tyrosine residues 740 and 751, which bind the 85 kDa subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to...
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKBa or RacPK), Akt2 (also designated PKB-b or RacPK-b) and Akt3 (also designated PKB-g or thyoma viral proto-oncogene 3). Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-b tyrosine residues 740 and 751, which bind the 85 kDa subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to...
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Shipped In
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Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Monoclonal Antibodies
SUBCLASS
Protein Kinases
APPLICATION
WB
CLONE NUMBER
SK703
ACCESSION#
NP_001014431
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Supernatant
PHYSICAL FORM
Supplied as a liquid in 0.05% sodium azide.
GRADE
Supernatant
ANTIBODY TYPE
Mab
HOST SPECIES
human
ISOTYPE
IgG
CROSS REACTIVITY
Hu Mo
IMMUNOGEN
Peptide containing a pSer that corresponds to amino acid position 473 of human Akt1/PKBa. Species Sequence homology: rat, bovine, chicken, Xenopus.
SPECIFIC ACTIVITY
Recognizes human phosphorylated Akt1/PKB alpha. Species crossreactivity: mouse. Cross-reactivity to phosphorylated Akt2 and Akt3 likely based on sequence homology.
SWISS PROT#
P31749
COMMODITY CODE
30021010
HOST
rabbit
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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