KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 Sam68, p62, GAP-Associated Tyrosine Phosphoprotein p62, Src-associated in mitosis 68kD protein, p21 Ras GTPase-activating protein-associated p62)

SAM68 is a tyrosine-phosphorylated, SRC-associated protein in mitotic cells. SAM68 protein contains 3 N-terminal proline-rich sequences, followed by a KH domain embedded within a STAR domain, 3 more proline-rich sequences, a C-terminal tyrosine-rich region, which contains a domain similar to the SRGY domain of RNA-binding proteins, and a putative nuclear localization signal. SAM68 has a calculated molecular mass of 48.2kD, but it migrated as a 68kD protein on SDS-PAGE gels. Northern blot analysis detected a 3.1kb SAM68 transcript expressed at moderate levels in heart, brain, placenta, skeletal...