ANGPTL4 (Angiopoietin Like Protein 4, ARP4, FIAF, HFARP, NL2, PGAR, Pp1158, Fasting-Induced Adipose Factor, Hepatic Angiopoietin-Related Protein, Hepatic Fibrinogen/Angiopoietin-Related Protein)

Angiopoietin-related protein 4 is a  a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to...