ERAP2, NT (RAP2, LRAP, L-RAP, Endoplasmic Reticulum Aminopeptidase 2, Leukocyte-Derived Arginine Aminopeptidase)

The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer. Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response. Applications: Suitable for use in ELISA and Western Blot. Other applications not...