UHRF2 (E3 Ubiquitin-Protein Ligase UHRF2, Np95/ICBP90-like RING Finger Protein, Np95-like RING Finger Protein, Nuclear Protein 97, Nuclear zinc Finger Protein Np97, RING Finger Protein 107, UHRF2, NIRF, RNF107)

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple...