A total of eight mammalian PLC isozymes have been described (PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC y1, PLC y2, PLC delta1 and PLC delta2) with molecular weights ranging from 85 to 150 kDa. The y-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two y-type enzymes, but not the beta and delta isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC beta1, PLC beta2 and PLC beta3 is mediated by the alpha subunits of the Gq...
A total of eight mammalian PLC isozymes have been described (PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC y1, PLC y2, PLC delta1 and PLC delta2) with molecular weights ranging from 85 to 150 kDa. The y-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two y-type enzymes, but not the beta and delta isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC beta1, PLC beta2 and PLC beta3 is mediated by the alpha subunits of the Gq...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Polyclonal Antibodies
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by immunoaffinity chromatography.
APPLICATION
IHC WB
PHYSICAL FORM
Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
SUBCLASS
Enzymes, Phospholipase
HOST SPECIES
human
ISOTYPE
IgG
IMMUNOGEN
Synthetic phosphopeptide derived from human PLC β3 around the phosphorylation site of Serine 1105.
ANTIBODY TYPE
Pab
GRADE
Affinity Purified
CROSS REACTIVITY
Hu Mo Rt
SPECIFIC ACTIVITY
Recognizes endogenous levels of PLC beta3, phosphorylated S1105. Species Crossreactivity: Human, mouse, rat
COMMODITY CODE
30021010
HOST
rabbit
SWISS PROT#
Q01970
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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