IFIH1 (Interferon-induced Helicase C Domain-Containing Protein 1, Clinically amyopathic dermatomyositis Autoantigen 140kD, CADM-140 Autoantigen, Helicase with 2 CARD Domains, Helicard, Interferon-induced with Helicase C Domain Protein 1, Melanoma Differentiation-Associated Protein 5, MDA-5, Murabutide down-Regulated Protein, RIG-I-like Receptor 2, RLR-2, RNA Helicase-DEAD box Protein 116, IFIH1, MDA5, RH116)

Antiviral innate immunity depends on the combination of parallel pathways triggered by virus detecting proteins in the Toll-like receptor (TLR) family and RNA helicases, such as Rig-I (retinoic acid-inducible gene I) and MDA-5 (melanoma differentiation-associated antigen 5), which promote the transcription of type I interferons (IFN) and antiviral enzymes. TLRs and helicase proteins contain sites that recognize the molecular patterns of different virus types, including DNA, single-stranded RNA (ssRNA), double-stranded RNA (dsRNA), and glycoproteins. These antiviral proteins are found in different...