FAS (Tumor Necrosis Factor Receptor Superfamily Member 6, Apo-1 Antigen, Apoptosis-mediating, Surface Antigen FAS, FASLG Receptor, CD95, FAS, APT1, FAS1, TNFRSF6)

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno- surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FASbased mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is...