EXT2 (Exostosin-2, Glucuronosyl-N-acetylglucosaminyl-Proteoglycan/N, acetylglucosaminyl-Proteoglycan 4-alpha-N, acetylglucosaminyltransferase, Multiple exostoses Protein 2, Putative Tumor Suppressor Protein EXT2, EXT2)

Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the formation of exostoses (EXT), which are cartilage-capped bony protuberances mainly located on long bones . Two proteins associated with EXT, EXT1 and EXT2, form homo/heteromeric complexes in vivo, which leads to the accumulation of both proteins in the Golgi apparatus . EXT1 and EXT2 are endoplasmic reticulum-localized type II transmembrane glycoproteins that possess, or are tightly associated with, glycosyltransferase activities involved in the polymerization of the glycosaminoglycan, heparan sulfate (HS)....