Egr-1/2 (Early Growth Response Protein 1, EGR-1, AT225, Nerve Growth Factor-induced Protein A, NGFI-A, Transcription Factor ETR103, Transcription Factor Zif268, Zinc Finger Protein 225, Zinc Finger Protein Krox-24, EGR1, KROX24, ZNF225, E3 SUMO-Protein Ligase EGR2, AT591, Early Growth Response Protein 2, EGR-2, Zinc Finger Protein Krox-20, EGR2, KROX20)

Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92% identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle...