DAP (DAP 1, Dap, DAP-1, DAP1_HUMAN, Death Associated Protein 1, Death Associated Protein, Death-Associated Protein 1, MGC99796, OTTHUMP00000161670, OTTHUMP00000221331)

In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved cytoplasmic region called the “death domain”. DAP-1 (for death associated protein-1) interacts with the death domain of TNF-R1 and can trigger programmed cell death in a variety of cell lines, as well as suppress NFκB/Rel activity. DAP-3 is a positive mediator of programmed cell death; overexpressed intact full-length protein is required in order...