TYW1 (tRNA Wybutosine-synthesizing Protein 1 Homolog, Radical S-adenosyl Methionine and Flavodoxin Domain-containing Protein 1, tRNA-yW-synthesizing Protein, RSAFD1, FLJ10900, MGC23001, MGC60291)

TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732aa protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome...