MAP3K4 (MEKK4 (MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1, Mitogen-activated Protein Kinase Kinase Kinase 4, MAP Three Kinase 1, MAPK/ERK Kinase Kinase 4, FLJ42439, KIAA0213) (APC)

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus....