KiSS-1 has been reported to suppress metastases of melanomas and breast carcinomas without affecting tumorigenicity. Human KiSS-1 transcripts are predominately expressed in the brain and placenta. Expression of KiSS-1 reduces the level of NFkB p50/p65 binding to the MMP9 promoter and correlates with diminished expression of the 92kD type IV collagenase (MMP-9). KiSS-1 may regulate events downstream of cell-matrix adhesion in mechanisms involving cytoskeletal reorganization.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Optimal dilutions...
KiSS-1 has been reported to suppress metastases of melanomas and breast carcinomas without affecting tumorigenicity. Human KiSS-1 transcripts are predominately expressed in the brain and placenta. Expression of KiSS-1 reduces the level of NFkB p50/p65 binding to the MMP9 promoter and correlates with diminished expression of the 92kD type IV collagenase (MMP-9). KiSS-1 may regulate events downstream of cell-matrix adhesion in mechanisms involving cytoskeletal reorganization.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Optimal dilutions...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Polyclonal Antibodies
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by Protein A affinity chromatography.
APPLICATION
WB
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
SUBCLASS
Tumor Suppressors
HOST SPECIES
human
ISOTYPE
IgG
IMMUNOGEN
Full length human KISS1, aa1-138 (NP_002247.3).
ACCESSION#
BC022819.1, NP_002247.3
ANTIBODY TYPE
Pab
GRADE
Affinity Purified
CROSS REACTIVITY
Hu
SPECIFIC ACTIVITY
Recognizes human KISS1.
COMMODITY CODE
30021010
HOST
rabbit
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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