IGFBP3 (Insulin-like Growth Factor-binding Protein 3, IBP-3, IGF-binding Protein 3, IGFBP-3, IBP3) (AP)

Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9kD cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Applications: Suitable...