HLA-DPA1 (HLASB, HLA Class II Histocompatibility Antigen, DP alpha 1 Chain, DP(W3), DP(W4), HLA-SB alpha Chain, MHC Class II DP3-alpha, MHC Class II DPA1) (APC)

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain...