DTX2 (Probable E3 Ubiquitin-protein Ligase DTX2, RING Finger Protein 58, Protein Deltex-2, Deltex2, hDTX2, KIAA1528, RNF58, MGC71098) (Biotin)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended...