CPEB (CPEB1, Cytoplasmic Polyadenylation Element-binding Protein 1, CPE-BP1, CPE-binding Protein 1, h-CEBP, hCPEB-1, FLJ13203, MGC34136, MGC60106) (PE)

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites;...