COX1 (Prostaglandin G/H Synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin-Endoperoxide Synthase 1, Prostaglandin H2 Synthase 1, PGH Synthase 1, PGHS-1, PHS 1, PTGS1) (Biotin)

COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory...