CD44 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1) (Biotin)

CD44 is the receptor for hyaluronan. The interaction between CD44 and hyaluronan may mediate binding of cells to basement membranes. Several CD44 isoforms or variants arise from alternative splicing of mRNA transcribed from a single gene located on chromosome 11. Most cell types express the st andard CD44, while the expression of the isoforms resulting from the alternative splicing is of limited distribution. The CD44 st andard form is observed to associate with Src and the Src family members Fyn and Yes. Stimulation of CD44 st andard expressed by SK-OV-3.ipl ovarian cancer cells by the addition...