CD109 (CD109 Antigen, 150kD TGF-beta-1-binding Protein, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 7, Platelet-specific Gov Antigen, p180, r150, CPAMD7, DKFZp762L1111, FLJ38569, FLJ41966, RP11-525G3.1) (Biotin)

CD109 is a GPI-anchored member of the A2-macroglobulin (A2M) and complement family of proteins. Mature human CD109 contains a bait region with recognition sequences for multiple proteases, an internal thioester bond, and a domain similar to the receptor binding domain of A2M. Cleavage of A2M family proteins within the bait region activates the thioester bond to promote covalent bonding to nucleophilic groups in adjacent molecules. Within the region included in the recombinant protein used for immunization, human CD109 shares 71%-73% aa sequence identity with mouse and rat CD109. CD109 is expressed...