Specifications
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
GENE ID
https://www.ncbi.nlm.nih.gov/gene/156
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
ANTIBODY TYPE
WB (1:250); optimal dilutions for assays should be determined by the user.
PURIFICATION
Peptide Affinity Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
IMMUNOGEN
A phospho-specific peptide corresponding to residues surrounding Tyr356 of human GRK2 (AA353-359)
SPECIFICITY
Detects 79.574 kDa.
STORAGE BUFFER
PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2707006
CELLUAR LOCALIZATIONS
Cytoplasm | Cell Membrane
TISSUE SPECIFICITY
Expressed in peripheral blood leukocytes.
SCIENTIFIC BACKGROUND
G protein-coupled receptor kinases (GRKs) belong to a class of enzymes that regulate signal transduction. At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase: GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
RESEARCH AREA
Neuroscience | Neurotransmission | Neurotransmitter Receptors | Cell Signaling
ALTERNATIVE NAMES
ADRBK1 Antibody, Adrenergic beta receptor kinase 1 Antibody, ARBK1_HUMAN Antibody, BARK Antibody, BARK1 Antibody, Beta adrenergic receptor kinase 1 Antibody, Beta ARK 1 Antibody, G protein coupled receptor kinase 2 Antibody
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