Specifications
RESEARCH AREA
Cell Signaling | Protein Phosphorylation | Serine / Threonine Kinases | Aurora
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
GENE ID
https://www.ncbi.nlm.nih.gov/gene/6795
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
ANTIBODY TYPE
WB (1:250); optimal dilutions for assays should be determined by the user.
PURIFICATION
Peptide Affinity Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
GENE ALIAS
Aurora C (pSer193)
IMMUNOGEN
A phospho-specific peptide corresponding to residues surrounding Ser193 of human Aurora C (AA190-196)
SPECIFICITY
Detects 35.591 kDa.
STORAGE BUFFER
PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2706989
CELLUAR LOCALIZATIONS
Chromosome | Cytoplasm | Cytoskeleton
SCIENTIFIC BACKGROUND
Aurora C is part of the larger AURA family of serine/threonine kinases and is a key regulator of mitotic cell division. It is involved in regulating microtubule formation and the assembly of the mitotic spindle responsible for chromosome segragation during mitosis. AURA activity is cell cycle dependent with the greatest activity occuring during mitosis. The overexpression of AURA has been well documented in many malignant cancers including breast, ovarian, colon, prostate and neuroblastomas. Overexpression of AURA appears to override checkpoints in cell cycle progression leading to increased cell division and proliferation.
ALTERNATIVE NAMES
AURKC Antibody, AIE2 Antibody, ARK3 Antibody, Aurora/lpl1 related kinase 3 Antibody, Serine threonine protein kinase 13 Antibody, STK13 Antibody, SPGF5 Antibody, IPL-1/STK13/Aurora C Antibody
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