Specifications
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
APPLICATION
WB, ELISA, FCM
GENE ID
https://www.ncbi.nlm.nih.gov/gene/854192
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
ANTIBODY TYPE
WB (1:2500); optimal dilutions for assays should be determined by the user.
REACTIVITY SPECIES
Mouse | Yeast
PURIFICATION
Rabbit Antiserum
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
IMMUNOGEN
Yeast Sti1p raised against peptide(CDINQSNSMPKEPET)-KLH fusion
SPECIFICITY
Detects ~ 66kDa.
STORAGE BUFFER
Rabbit Antiserum, PBS, 50% glycerol, *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2704178
CELLUAR LOCALIZATIONS
Cytoplasm | Nucleus
SCIENTIFIC BACKGROUND
The stress inducible protein Sti1p is also commonly known as HSP70-HSP90 organization protein (HOP). It is located in diverse cellular regions and can move between the cytoplasm and the nucleus. It functions to reversibly link together the protein chaperones HSP70 and HSP90. HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a and TPR2b. HSP70 binding has been localized to TRP1 and sp90 binding have been localized to TPR2a (1). It has also been found to modulate the chaperone activities of the linked proteins and possible interacts with other chaperones and proteins. It has also been found to participate in other complexes besides the HSP70/HSP90 one (2). HOP is closely related to human 63kDa protein that is sensitive to simian virus SV40 transformation, and is related to the yeast heat-shock- responsive STI1 gene product (3, 4).
REFERENCES
1. Flom G., Behal R.H., Rosen L., Cole D.G., Johnson J.L. (2007) Biochem J. 404(1): 159-167.
2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt3): 789-796.
3. Honore B.H., et al. (1992) J Biol Chem. 267: 8485- 8491.
4. Nicolet C.M., et al. (1989) Mol Cell Bio. 9: 3638-3646.
RESEARCH AREA
Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins
ALTERNATIVE NAMES
STIP1 Antibody, Sti1 yeast Antibody, Hop Antibody, HSC70/HSP90 organizing protein Antibody, Epididymis secretory sperm binding protein Li 94n antibody, HEL S 94n antibody, Hop antibody, HSC70/HSP90 organizing protein antibody, HSC70/HSP90-organizing protein antibody, IEF SSP 3521 antibody, NY REN 11 antigen antibody, P60 antibody, Renal carcinoma antigen NY-REN-11 antibody, STI1 antibody, STI1L antibody, STIP1 antibody, Stress induced phosphoprotein 1 antibody, Stress-induced-phosphoprotein 1 antibody, Transformation sensitive protein IEF SSP 3521 antibody, Transformation-sensitive protein IEF SSP 3521 antibody
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