SIK1 Antibody (pThr182): ATTO 594

Polyclonal

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Canada

WB, AM

https://www.ncbi.nlm.nih.gov/gene/102724428

NP_775490

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

WB (1:250); optimal dilutions for assays should be determined by the user.

Rabbit

Human

ATTO 594

Peptide Affinity Purified

ISO 9001:2015

SIK1 (pThr182)

A phospho-specific peptide corresponding to residues surrounding Thr182 of human SIK1 (AA179-185)

Detects 84.902 kDa.

PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2709879

Cytoplasm | Nucleus

Highly expressed in the cornea, keratinocytes, and B-lympocytes. Lower expression found in many organs.

SIK1 (salt-inducible kinase 1), also known as SNF1LK or MSK, is a 783 amino acid protein that contains one UBA domain and one protein kinase domain and belongs to the Ser/Thr protein kinase family. Localized to both the nucleus and the cytoplasm, SIK1 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation. Additionally, SIK1 has a potential role in regulation of the G2/M cell cycle transition, as well as in inhibitory control of CREB protein function.

Cell Signaling | Epigenetics and Nuclear Signaling | Chromatin Modifying Enzymes | DNA Acetylation | HDACS | Cell Signaling | Protein Phosphorylation | Serine / Threonine Kinases | Cardiovascular System | Heart | Cardiogenesis | Cardiomyocyte Precursors | Myocardial Regeneration

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