PAK5 Antibody (pSer602)

Polyclonal

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Canada

WB, AM

https://www.ncbi.nlm.nih.gov/gene/57144

NP_065074

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

WB (1:250); optimal dilutions for assays should be determined by the user.

Rabbit

Human

Unconjugated

Peptide Affinity Purified

ISO 9001:2015

PAK5 (pSer602)

A phospho-specific peptide corresponding to residues surrounding Ser602 of human PAK5 (AA599-605)

Detects 80.745 kDa.

PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2709209

Mitochondrion | Cytoplasm | Nucleus

Highly expressed in the brain.

PAK7 is a serine/theonine protein kinase activated by Rac/cdc42 and thus involved in regulation of cytoskeleton, cell surival and proliferation through RAF1 signalling. It phosphosphorylates BAD and prevents apoptosis. It is also involved in microtuble stablization, neurite outgrowth and development. It can destablize F-acting networks and eliminate stress fibres and focal adhesions. Pak7 expression provides a survival and could contribute to oncogenesis in this way.

Cell Signaling | Protein Phosphorylation | Serine / Threonine Kinases | Neuroscience | Neurogenesis | Cancer | Apoptosis | Intracellular

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