Kir6.1 Antibody, Clone S366-60: ATTO 594

Monoclonal

Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.

Canada

WB, IHC, ICC/IF

https://www.ncbi.nlm.nih.gov/gene/25472

S366-60

NP_058795.3

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1 mg/ml

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Mouse

IgG2A

Human | Mouse | Rat

ATTO 594

Protein G Purified

ISO 9001:2015

Kir6.1

Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1

Detects ~45kDa.

PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2702553

Membrane

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).

1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.

Neuroscience | Ion channels | Potassium Channels | Inward-Rectifying Potassium Channels | Cancer

ATP-sensitive inward rectifier potassium channel 8 Antibody, Potassium channel inwardly rectifying subfamily J member 8 Antibody, uKATP-1 Antibody, Kcnj8 Antibody