Vildagliptin

Small Molecules

Inhibitor

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Canada

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Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

White powder

>98% (HPLC); NMR (Conforms)

ISO 9001:2015

Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent.

1. B Balas et al., (2007) J. Clin. Endocrinol. Metab. 92:1249. 2. B Ahren et al., (2004) J. Clin. Endocrinol. Metab. 89:2078.

Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Atherosclerosis | Diabetes Associated

(S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237