GF109203X

Small Molecules

Inhibitor

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Canada

C4=C(C3=C(C1=C[NH]C2=CC=CC=C12)C(=O)NC3=O)C5=C([N]4CCCN(C)C)C=CC=C5

QMGUOJYZJKLOLH-UHFFFAOYSA-N

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Red solid

≥98% (TLC)

ISO 9001:2015

GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.

1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781. 2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002. 3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180. 4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide, 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I