E-4031

Small Molecules

Inhibitor

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Canada

CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.O.O.Cl.Cl

AJNFQUKPBCGJKX-UHFFFAOYSA-N

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

White solid

>98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39); NMR conforms

ISO 9001:2015

E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).

1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68. 2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148. 3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215. 4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503. 5. Miyake K., et al. (1990) J Med Chem. 33: 903.

Neuroscience | Ion Channels

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride, dihydrate