E-4031
StressMarq Biosciences Inc.
SKU / CAT#: SIH-317-10MG
$15700
usd
$15.70/mg
SIH-317-10MG

E-4031

StressMarq Biosciences Inc.
SKU / CAT#: SIH-317-10MG
MPN: SIH-317-10MG
$15700
usd
$15.70/mg
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Available
SHIPS Aug 29th
Available
SHIPS Aug 29th
SKU
Unit size / Options
Availability
Price
No products found
Description
Herg channel blocker
Herg channel blocker
Shipping & Handling
Shipped In
Ambient
Safety & Storage
Storage Temperature
-20ºC
Safety Statement
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Regulatory & Compliance
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Specifications
CLASS
Small Molecules
SUBCLASS
Inhibitor
SHIPPING NOTES
Shipped Ambient. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
COUNTRY OF ORIGIN
Canada
SMILES
CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.O.O.Cl.Cl
INCHI KEY
AJNFQUKPBCGJKX-UHFFFAOYSA-N
UNSPSC CODE
41116105.0
RIDADR
Non-hazardous
UN NUMBER
Non-hazardous
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
COLOR
White solid
PURITY
>98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39); NMR conforms
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
SCIENTIFIC BACKGROUND
E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
REFERENCES
1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68. 2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148. 3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215. 4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503. 5. Miyake K., et al. (1990) J Med Chem. 33: 903.
RESEARCH AREA
Neuroscience | Ion Channels
ALTERNATIVE NAMES
N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride, dihydrate
Questions & Answers (0)
Citations (0)
E-4031
E-4031
Shipping & Handling
Shipped In
Ambient
Safety & Storage
Storage Temperature
-20ºC
Safety Statement
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Regulatory & Compliance
Badge
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