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PMS2 Antibody / PMS1 homolog 2
SKU / CAT#: V8728-20UG
$21900
usd
$10.95/UG
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V8728-20UG

PMS2 Antibody / PMS1 homolog 2

NSJ Bioreagents
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SKU / CAT#: V8728-20UG
MPN: V8728-20UG
$21900
usd
$10.95/UG
Available
SHIPS Jul 7th
Available
SHIPS Jul 7th
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Description
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized...
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the recombinant PMS2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This recombinant PMS2 antibody is available for research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
SkLhDrecombinant-pms2-antibody-pms2-4373r-v8728
Specifications
CLASS
Primary Antibodies
SUBCLASS
Recombinant Monoclonal
UNIPROT ID
P54278
CLONE NUMBER
PMS2/4373R
*USAGE / SAFETY STATEMENT
This recombinant PMS2 antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
IHC-P
HOST SPECIES
Rabbit
ISOTYPE
Rabbit IgG
REACTIVITY SPECIES
Human
CLONALITY
Recombinant Rabbit Monoclonal
PURIFICATION
Protein A affinity chromatography
IMMUNOGEN
A portion of amino acids 1-100 from the human protein was used as the immunogen for the recombinant PMS2 antibody.
STORAGE BUFFER
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
APPLICATION DETAILS
Immunohistochemistry (FFPE): 1-2ug/ml
APPLICATION NOTES
Optimal dilution of the recombinant PMS2 antibody should be determined by the researcher.
LOCALIZATION
Nuclear
Questions & Answers (0)
Citations (0)
IHC staining of FFPE human colon carcinoma with recombinant PMS2 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human colon carcinoma with recombinant PMS2 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human colon carcinoma with recombinant PMS2 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using PMS2 antibody. These results demonstrate the foremost specificity of the PMS2/4373R mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the recombinant PMS2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This recombinant PMS2 antibody is available for research use only.
Regulatory & Compliance
Badge
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