CD146 Antibody / MCAM / MUC18
SKU / CAT#: V7942SAF-100UG
$49900
usd$4.99/UG
CD146 Antibody / MCAM / MUC18
NSJ BioreagentsSKU / CAT#: V7942SAF-100UG
MPN: V7942SAF-100UG
$49900
usd$4.99/UG
Available
SHIPS Jul 4th
Available
SHIPS Jul 4th
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Description
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the MCAM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This MCAM antibody is available for research use only.
Regulatory & Compliance
Technical Documents
Datasheet (1)
Specifications
CLASS
Primary Antibodies
SUBCLASS
Monoclonal
UNIPROT ID
P43121CLONE NUMBER
MCAM/3048
*USAGE / SAFETY STATEMENT
This MCAM antibody is available for research use only.
FORMAT
Purified (Sodium Azide Free)
APPLICATION.1
IHC-P
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG2b, kappa
REACTIVITY SPECIES
Human
CLONALITY
Monoclonal (mouse origin)
PURIFICATION
Protein G affinity chromatography
IMMUNOGEN
A recombinant human partial protein (amino acids 226-374) was used as the immunogen for the MCAM antibody.
STORAGE BUFFER
1 mg/ml in 1X PBS; BSA free, sodium azide free
APPLICATION DETAILS
Immunohistochemistry (FFPE): 1-2ug/ml
APPLICATION NOTES
Optimal dilution of the antibody should be determined by the researcher.
LOCALIZATION
Cell surface, cytoplasmic
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the MCAM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This MCAM antibody is available for research use only.
Regulatory & Compliance
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