Ku70 + Ku80 Antibody
SKU / CAT#: V7202-20UG
$21900
usd$10.95/UG
Ku70 + Ku80 Antibody
NSJ BioreagentsSKU / CAT#: V7202-20UG
MPN: V7202-20UG
$21900
usd$10.95/UG
Available
SHIPS Jun 2nd
Available
SHIPS Jun 2nd
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Description
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the Ku70 + Ku80 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This Ku70 + Ku80 antibody is available for research use only.
Regulatory & Compliance
Technical Documents
Datasheet (1)
Specifications
CLASS
Primary Antibodies
SUBCLASS
Monoclonal
GENE ID
https://www.ncbi.nlm.nih.gov/gene/2547
CLONE NUMBER
LKAP1-1
*USAGE / SAFETY STATEMENT
This Ku70 + Ku80 antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
FACS, IF
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG1, kappa
REACTIVITY SPECIES
Human
CLONALITY
Monoclonal (mouse origin)
PURIFICATION
Protein G purified
IMMUNOGEN
A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.
STORAGE BUFFER
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
APPLICATION DETAILS
Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 1-2ug/ml
APPLICATION NOTES
Titering of the Ku70 + Ku80 antibody may be required for optimal performance.
LOCALIZATION
Nuclear
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the Ku70 + Ku80 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This Ku70 + Ku80 antibody is available for research use only.
Regulatory & Compliance
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