Topoisomerase II alpha Antibody / TOP2A
SKU / CAT#: V3442-100UG
$49900
usd$4.99/UG
Topoisomerase II alpha Antibody / TOP2A
NSJ BioreagentsSKU / CAT#: V3442-100UG
MPN: V3442-100UG
$49900
usd$4.99/UG
Available
SHIPS Apr 25th
Available
SHIPS Apr 25th
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Description
This mAb recognizes an ~170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
This mAb recognizes an ~170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the TOP2A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This TOP2A antibody is available for research use only.
Regulatory & Compliance
Technical Documents
Datasheet (1)
Specifications
CLASS
Primary Antibodies
SUBCLASS
Monoclonal
GENE ID
https://www.ncbi.nlm.nih.gov/gene/7153
UNIPROT ID
P11388CLONE NUMBER
TOP2A/1362
*USAGE / SAFETY STATEMENT
This TOP2A antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
WB, IF, IHC-P
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG2b, kappa
REACTIVITY SPECIES
Human
CLONALITY
Monoclonal (mouse origin)
PURIFICATION
Protein G affinity chromatography
IMMUNOGEN
Amino acids 1352-1493 from the human protein were used as the immunogen for this TOP2A antibody.
STORAGE BUFFER
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
APPLICATION DETAILS
Western blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
APPLICATION NOTES
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TOP2A antibody to be titered up or down for optimal performance.
LOCALIZATION
Nuclear
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the TOP2A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This TOP2A antibody is available for research use only.
Regulatory & Compliance
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