Cystic fibrosis transmembrane conductance regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (MDR1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine,...
Cystic fibrosis transmembrane conductance regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (MDR1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine,...
Shipping & Handling
Shipped In
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Safety & Storage
Storage Temperature
Store the CFTR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This CFTR antibody is available for research use only.
This CFTR antibody is available for research use only.
FORMAT
Purified (Sodium Azide Free)
SUBCLASS
Monoclonal
CLONE NUMBER
CFTR/1341
APPLICATION.1
IHC-P
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG1, kappa
REACTIVITY SPECIES
Human
CLONALITY
Monoclonal (mouse origin)
PURIFICATION
Protein G affinity chromatography
IMMUNOGEN
Human recombinant protein was used as the immunogen for this CFTR antibody.
STORAGE BUFFER
1 mg/ml in 1X PBS; BSA free, sodium azide free
APPLICATION DETAILS
Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT
APPLICATION NOTES
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CFTR antibody to be titered up or down for optimal performance.
LOCALIZATION
Cell surface, cytoplasmic
GENE ID
https://www.ncbi.nlm.nih.gov/gene/1080
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the CFTR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This CFTR antibody is available for research use only.
Regulatory & Compliance
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