This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Shipping & Handling

Shipped In

Cold Packs

Safety & Storage

Storage Temperature

Aliquot the Complement factor H antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Safety Statement

This Complement factor H antibody is available for research use only.

Regulatory & Compliance

Technical Documents

Datasheet (1)

dttPMcomplement-factor-h-antibody-f54343

Specifications

CLASS

Primary Antibodies

SUBCLASS

Polyclonal

UNIPROT ID

P08603

*USAGE / SAFETY STATEMENT

This Complement factor H antibody is available for research use only.

FORMAT

Purified

APPLICATION.1

IHC-P, WB, IF

HOST SPECIES

Rabbit

ISOTYPE

Rabbit IgG

REACTIVITY SPECIES

Human

CLONALITY

Polyclonal (rabbit origin)

PURIFICATION

Antigen affinity purified

IMMUNOGEN

A portion of amino acids 751-780 from the human protein was used as the immunogen for the Complement factor H antibody.

STORAGE BUFFER

In 1X PBS, pH 7.4, with 0.09% sodium azide

APPLICATION DETAILS

Immunohistochemistry (FFPE): 1:25,Western blot: 1:500-1:2000,Immunofluorescence: 1:25

APPLICATION NOTES

The stated application concentrations are suggested starting points. Titration of the Complement factor H antibody may be required due to differences in protocols and secondary/substrate sensitivity.