Specifications
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURIFICATION
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
FORMULATION
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
IMMUNOGEN
The antiserum was produced against synthesized peptide derived from human Fyn around the phosphorylation site of Tyr530. AA range:488-537
SPECIFICITY
Phospho-Fyn (Y530) Polyclonal Antibody detects endogenous levels of Fyn protein only when phosphorylated at Y530.
BACKGROUND
FYN proto-oncogene, Src family tyrosine kinase(FYN) Homo sapiens This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008],
PROTEIN NAME
Tyrosine-protein kinase Fyn
HUMAN SWISS PROT NO.
P06241
MOUSE SWISS PROT NO.
P39688
STORAGE STABILITY
-20°C/1 year
OTHER NAME
FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
FUNCTION
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Manganese.,enzyme regulation:Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.,function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1
SUBCELLULAR LOCATION
nucleus,mitochondrion,endosome,cytosol,actin filament,plasma membrane,postsynaptic density,extrinsic component of cytoplasmic side of plasma membrane,membrane raft,
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