Specifications
GENE ID
https://www.ncbi.nlm.nih.gov/gene/6722;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURIFICATION
Antigen affinity purification.
IMMUNOGEN
Synthetic peptide corresponding to residues near the C terminal of human serum response factor (c-fos serum response element-binding transcription factor)
SPECIFICITY
The antibody detects endogenous levels of total SRF protein.
BACKGROUND
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
FORM OF ANTIBODY
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
RECOMMENDED DILUTIONS
Western blotting: 1:200-1:1000<br/>Immunohistochemistry: 1:50-1:200
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