Specifications
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURIFICATION
Antigen affinity purification.
IMMUNOGEN
Full length fusion protein
GENE ID
https://www.ncbi.nlm.nih.gov/gene/1280;
SPECIFICITY
The antibody detects endogenous levels of total COL2A1 protein.
BACKGROUND
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
ALTERNAME
AOM; ANFH; SEDC; COL11A3
FORM OF ANTIBODY
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
RECOMMENDED DILUTIONS
Western blotting: 1:200-1:1000<br/>Immunohistochemistry: 1:15-1:50