1-O-Acetylbritannilactone

1-O-Acetylbritannilactone is a sesquiterpene lactone that has been found in I. britannica and has diverse biological activities. It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and nuclear translocation of NF-κB in primary rat aorta vascular smooth muscle cells (VSMCs). 1-O-Acetylbritannilactone (5 and 10 µM) inhibits VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs). It reduces tumor growth in an A549 mouse xenograft model when administered at a dose of 12 mg/kg per day.