GNE-6640 is an inhibitor of ubiquitin-specific protease 7 (USP7; IC50 = 0.75 µM). It is selective for USP7 over USP47 and USP5 (IC50s = 20.3 and >200 µM, respectively). GNE-6640 enhances ubiquitination of the USP7 substrate MDM2 in HCT116 colon cancer cells (IC50 = 0.23 µM) and reduces cell viability in a panel of 108 cell lines (IC50s = <10 µM for all). GNE-6640 (10-70 µM) enhances apoptosis induced by doxorubicin (Item No. 15007) or cisplatin (Item No. 13119) in MCF-7 and U2OS cancer cells, respectively.

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WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

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Technical Documents

Datasheet (1)

jQagg33751.pdf

MSDS (1)

ZKqIE33751m.pdf

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Shipping & Handling

Shipped In

Room Temperature in continental US; may vary elsewhere

Safety & Storage

Storage Temperature

-20°C

Safety Statement

WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Regulatory & Compliance

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