Osanetant is a neurokinin-3 (NK3) receptor antagonist (Ki = 0.21 nM in CHO cells expressing the human receptor). It is selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 0.02 µM, respectively). Osanetant inhibits contractions and acetylcholine release induced by neurokinin B (Item No. 24542) in isolated guinea pig ileal strips in a concentration-dependent manner. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil, eosinophil, and lymphocyte infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Osanetant (5 and 10 mg/kg) increases...
Osanetant is a neurokinin-3 (NK3) receptor antagonist (Ki = 0.21 nM in CHO cells expressing the human receptor). It is selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 0.02 µM, respectively). Osanetant inhibits contractions and acetylcholine release induced by neurokinin B (Item No. 24542) in isolated guinea pig ileal strips in a concentration-dependent manner. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil, eosinophil, and lymphocyte infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Osanetant (5 and 10 mg/kg) increases...
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Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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