Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity. It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM. Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinsons disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine (Item No. 13242) and chloroquine (Item No. 14194). It reduces increases in methamphetamine-induced...
Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity. It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM. Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinsons disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine (Item No. 13242) and chloroquine (Item No. 14194). It reduces increases in methamphetamine-induced...
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Room Temperature in continental US; may vary elsewhere
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-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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